DOA (deforming osteoarthritis) of the knee and ankle joints
Deforming osteoarthritis (DOA) is a progressive disease characterized by premature aging of bone tissues. This condition represents a highly prevalent pathology. The high-risk cohort predominantly includes individuals over the age of 40–50; however, the disease can also manifest at an earlier age.
Persistent arthralgia within the joint zone becomes a definitive sign of DOA. The pain may manifest during prolonged sitting, at the initiation of movement, or during physical exertion. Other clinical symptoms include articular crepitus during movement, lower extremity length discrepancy, and claudication.
The pathogenesis initiates with the degradation of articular cartilage. Articular gliding is disrupted, triggering an inflammatory response that exacerbates tissue damage. The joints lose elasticity and mechanical strength. Subchondral cysts and specific osteophytic overgrowths develop within the affected area.